Submission 18

Submission 18

Here we describe a collaboration between UniProt and IMGT®, the international ImMunoGeneTics information system® that aims to provide representative sequences for functional immunoglobulin (IG) genes of the human reference genome through UniProtKB/Swiss-Prot.

Immunoglobulin heavy and light chains are created during B cell maturation by DNA rearrangements in the IG multigene loci of variable (V), diversity (D), and joining (J) genes, resulting in V-(D)-J rearranged genes which are then spliced to constant (C) genes – producing an enormous number of potential sequence combinations. In UniProtKB/Swiss-Prot we have curated representative peptides corresponding to the functional germline D- and J-region genes as well as the products of all functional V- and C-region genes. This set of 141 UniProtKB/Swiss-Prot entries are identical to the reference genome (GRCh38), use official nomenclature from IMGT/GENE-DB (approved by HGNC and endorsed by NCBI Gene and the IUIS-Nomenclature Subcommittee for Immunoglobulins and T cell receptors), and are directly linked to the IMGT® resource, which provides a comprehensive human IG genomic repertoire of 927 known alleles from 462 functional and non-functional genes and a wealth of additional information concerning immunoglobulins or antibodies.