Invited Talk 4

Invited Talk 4

The Reactome Pathway Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations - an extended version of a classic metabolic map, in a single consistent pathway data model. Reactome functions both as an archive of biological processes and as a tool for discovering unexpected functional relationships in data such as gene expression profiles or somatic mutation catalogues from tumor cells. Reactome curation is focused on human; pathways for 20 model organisms are provided through orthology-based inference.

Reactome provides a multi-scale visualisation interface, from a genome-wide overview to detailed, SBGN-style diagrams of biochemical reactions [1]. Recently, we have added a layer of textbook-style, high level diagrams, providing an overview of the pathways for a larger group of biochemical processes, for example "Metabolism of RNA" [2]. The diagrams are not static images, but interactive SVGs, where the clickable regions constitute the links to the next lower level in the Reactome pathway hierarchy. These diagrams are developed in an iterative process by a professional graphic designer and the curator(s) of the involved pathways. Graphical icons used in the overview diagrams are also provided individually through the Reactome icon library [3] for download and re-use in biological illustrations within and beyond the pathway domain. This library is also open for community contributions, with author attribution at the level of individual icons.

[1] Sidiropoulos K, et al. Reactome enhanced pathway visualization. Bioinformatics. 2017 Nov 1;33(21):3461-3467.

[2] https://reactome.org/PathwayBrowser/#/R-HSA-8953854

[3] https://reactome.org/icon-lib

Figure 1: Reactome pathway overview diagram for "Metabolism of RNA"